Viagra Information and News Articles
(Latest information on Viagra)
The following represent a comprehensive list of Viagra
articles that address the use of
Viagra for the treatment of male impotence:
Viagra, Rationed
British Medical Journal
November, 2008
Viagra is Licensed in Europe but Rationed
in Britain
British Medical Journal
October, 2008
UK Issues Guidance On Prescribing Viagra
British Medical Journal
November, 2008
Study Shows Viagra Safe for Men with
Hypertension
Worldwide Biotech
October, 2008
Erectile Dysfunction Patients Remain
Satisfied With Viagra After Two Years, New Study Shows
PR Newswire
September, 2008
Using Viagra
Family Physician
September, 2008
Viagra Tale: How One Man Sought an
Impotence Cure - and Found One
News & World Report
October, 2008
New Study of Viagra in General Medical
Practice Confirms Safety Profile Established by Clinical Trials
PR Newswire
October, 2008
A MAN AGAIN ': Experts Praise a Pill that
Treats Impotence (the use of the Viagra, an impotence drug)
Maclean's
September, 2008
Viagra, Rationed
British Medical Journal
November, 2008
Frank Dobson's announcement on
prescribing Viagra was denounced by the BMA as "cruel and
unethical." But doctors found few allies in the press. As
Jennifer Trueland wrote in the Scotsman, the Viagra debate
"shows that the NHS has finite resources and that it cannot meet
every demand" The Evening Standard, however, was first into the
fray : "Doctors do not run the National Health Service:
taxpayers do. But try telling that to the British Medical
Association. It was in the interests of the taxpayers, and of
common sense, that the Health Secretary, Frank Dobson, announced
his new, binding guidelines.... The BMA needs to be slapped down
hard on this."
The
Independent argued that "rationing by queueing" was as old as
the NHS, and that, while the 1990s was "the Happy Decade" (thank
you Prozac and Viagra), it would "also be remembered as the
decade in which the rationing of healthcare started in Britain."
The BMA, it claimed, was more concerned about doctors'
priorities than those of the NHS--"as selfish and irresponsible
a vested interest as the worst of the flying pickets in the
1970s." Doctors had become rebels, and their leaders rabble
rousing trade unionists: "For the BMA to instruct its members to
defy the Government by prescribing as much Viagra as they think
is justified by `clinical need' until the guidelines take effect
is the kind of gesture politics which got Arthur Scargill where
he is today."
" Dobson's choice" as the media dubbed it,
centered around the health minister's belief that impotence
isn't life threatening and doesn't cause physical pain. "We
have to find a sensible balance between treating men with a
distressing condition and protecting the resources of the NHS to
deal with other conditions, for example," chose Mr Dobson,
"cancer, heart disease, and mental health problems." Apparently
not the mental anguish of impotent men, though.
General practitioner David Devlin told
the Daily Telegraph: "I think this is quite unfair.
I have more than 100 patients on Viagra and all are suffering
from impotence caused by psychological or physical disorders.
A lot of people consider
Viagra users to be promiscuous
men. This is not true."
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Andrew Marr of the Observer offered an
explanation: "We had reason to think that his [Dobson's]
contribution to the drugs debate would be to manufacture the
filthiest Viagra joke on the planet. Instead he has changed the
National Health Service forever. This is about values: and
unlike his jokes, Dobson's are decent to the core. A nation
which spends taxpayers' money on better erections, while leaving
old ladies to soil themselves and starve in under-staffed wards,
is sick indeed." Marr is convinced that Dobson's choice is the
"clearest act of national drugs rationing yet." Who could
disagree?
Mr Dobson was firm, doctors were defiant,
and Pfizer--manufacturer of Viagra--was furious but exploring
"all its options." For three days the controversy raged:
"Impotence is not a joke, say doctors", while "Impotence is not
really such a serious problem, claims Dobson" (Express 22
January). The Express applauded as "Dobson strikes right balance
on
Viagra" but added a new twist:
"And today The Express reveals that because the drug is
registered in Britain, this country's exchequer makes money from
every pill sold across the world--in theory, more than enough to
offset the costs of prescribing Viagra."
Confused? The Sun seemed to be as well. The
"Sun Man's Sex File" confessed: "Dear Mr Dobson, I am a Sun
journalist and I am on Viagra--when I can afford it" (22
January). not doing the trick then? "How dare you suddenly
change the rules of the NHS now, after I have spent the better
part of my working life paying into it? Viagra has been a
Godsend." Another Sun journalist, Richard Littlejohn, was
unhappy that the NHS should "legalise and supply Viagra."
Instead, he offered his own rationing test: "If you're strong
enough to get the cap off the bottle, you can buy it yourself."
Inevitably, the prime minister made one of
his regular forays into the tabloid press. "We have to be hard
on Viagra," he exclusively told the Mirror. "I personally
believe that the public understands very well that there are
certain severe medical conditions in relation to impotence that
should be treated on the NHS." Do they? "You have got to make a
choice as to priorities."
Rationing is the word the government dare
not mention--prioritization is more acceptable in "Third Way"
terminology--but everyone else is dispensing it freely. The
first rationing skirmishes have been won in the press by the
government, with doctors portrayed as power crazed idealists
rather than patients' advocates. Rationing is now dearly with
us, though the method of making it work remains elusive. Where
will the National Institute of Clinical Excellence fit in? How
might doctors' and patients' views be better considered?
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of the Viagra information topics
Viagra is Licensed in Europe but Rationed in Britain.
British Medical Journal
October, 2008
Admitting that the decision was primarily
because of cost, the health secretary, Frank Dobson, said:
"Media coverage of this drug to date has created expectations
that could prove a serious drain on the funds of the NHS. If
this were to happen, other patients could be denied the
treatment they need. I cannot allow this to happen. "
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He added: "The potential availability of
Viagra raises issues about the priority which should be given to
the treatment of impotence on the NHS." He told Channel 4 News
that he expected eventual "limited availability" of Viagral.
Stephen Thornton, chief executive of the
NHS Confederation, praised the government for realizing that
availability of
Viagra
on the NHS "would have led to huge financial problems and
organizational chaos for the health service." He also said that
Mr Dobson was right to "issue guidance to clinicians and health
service managers about how the drug should be rationed."
The Department of Health has advised health
authorities "not to support the provision of Viagra at NHS
expense to patients requiring treatment for
impotence, other than in
exceptional circumstances which they should require be cleared
in advance for them." It is not yet clear what these exceptional
circumstances would be. However, it was also emphasized that
"ministers have not made any decisions relating to the nature
and extent of any future availability of this drug as part of
NHS services."
The NHS spends about 12m [pounds
sterling] annually on impotence treatments, but with the
introduction of oral treatment, demand is expected to be much
higher than at present. The BMA has calculated that the annual
drug bill for
Viagra
would exceed 1bn [pounds sterling] ($1.6bn) a year, if all of
the men who might benefit were prescribed the drug. Pfizer
insists that the cost of treatment is closer to 50m [pounds
sterling] after five years.
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Roger Kirby, a consultant urologist at St
George's Hospital in London and honorary secretary of the
British Association of Urological Surgeons, was surprised that a
"breakthrough" treatment was rationed, while the NHS continued
to prescribe for constipation and warts. He has privately
prescribed Viagra for nearly 200 patients and found it "safe and
effective." To avoid massive waiting lists, GPs, if properly
educated, should be able to prescribe Viagra for patients with a
genuine clinical need, he said.
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of the Viagra information topics
UK Issues Guidance On Prescribing Viagra.
British Medical Journal
November, 2008
The UK government last week issued draft
guidance to doctors on when they could prescribe Viagra to
patients on the NHS. Doctors' representatives immediately
rejected the government's proposals as "cruel and unethical."
Frank Dobson, secretary of state for health,
said that GPs could prescribe Viagra and other drug treatments
for impotence only to patients who have undergone prostatectomy
or radical pelvic surgery, or have a spinal cord injury,
diabetes, multiple sclerosis, or single gene neurological
disease.
The minister says that NHS treatment
October also be available "in a hospital setting subject to
specialist assessment in those exceptional circumstances where
impotence is causing severe distress." Doctors will be advised
to restrict their prescribing of treatment for impotence to one
treatment a week. Patients not suffering from one of the named
conditions would be able to get a private prescription. The
pills cost about 8 [pounds sterling] each.
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Mr Dobson pointed out that if Viagra were
freely available the cost of treating impotence could increase
10-fold or more. He said that he wanted to keep spending to its
current level--estimated to be between 10m [pounds sterling] and
12m [pounds sterling] a year. Mr Dobson said, "We have to find a
sensible balance between treating men with a distressing
condition and protecting the resources of the NHS to deal with
other patients-for example, with cancer, heart disease, and
mental health problems."
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It concluded that there was no medical
reason why the drug should not be available on the NHS, nor why
it should not be prescribed by GPs with referral to hospital
specialists where appropriate. It also suggested that ministers
should consider the priority given to all the methods of
managing
impotence in the NHS relative to
treatments for other conditions, but that any decision should
take into account equity of access as well as availability of
resources.
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The BMA's General Practitioners Committee
took great exception to the proposals at its meeting last week.
It saw them as unworkable and said they made a cruel and
unethical distinction between acceptable and unacceptable forms
of impotence. The committee believes that it is wrong to
distinguish between patients according to the cause of their
impotence.
Members criticised the minister's
statement that "impotence is in itself neither life threatening,
nor does it cause physical pain." The chairman of the BMA
council, Dr Ian Bogle, said that if those were the criteria for
treatment "they exclude most of my life's work." Many patients
would have to be referred to hospital when they could be treated
by their GPs and this would increase consultants' workload.
Pfizer, which makes Viagra, has accused
the government of breaching one of the NHS's principles, that
medical treatment should be available to patients on the basis
of clinical need. The company says that the conditions specified
by Mr Dobson represent about 85% of those who could benefit
clinically from Viagra and that the minister has discriminated
against patients with heart and psychological problems.
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of the Viagra information topics
Study Shows Viagra Safe for Men with
Hypertension
Worldwide Biotech
September, 2008
An important study recently published in the
European Journal of Hypertension shows that Viagra, the
breakthrough oral treatment for
erectile dysfunction (ED), has
comparable efficacy for ED for men taking antihypertensive (high
blood pressure) medications concurrent with Viagra, as for men
treated with Viagra alone. As the largest analysis of clinical
trial data to date, the study assessed the efficacy and safety
of Viagra in men with ED who were already taking one or more
antihypertensive medications.
Erectile dysfunction
-- the inability to achieve or
maintain an erection sufficient for satisfactory sexual activity
-- is a common problem in men with high blood pressure. In
fact, some studies report that one-in-five men with high blood
pressure suffer from ED. According to the published study
results, taking one or more antihypertensive medications
(diuretics, beta blockers, alpha blockers, ACE inhibitors or
calcium channel blockers) had no effect on the effectiveness or
side effect profile of Viagra.
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"Along with the effect of hypertension
itself, some of the medicines used to treat high blood pressure
are felt to have a negative impact on erectile function," said
Dr. John Parker, Cardiologist, Mount Sinai Hospital and
University Health Network Hospitals. "The results of this study
of hypertensive men confirm that Viagra is safe and effective in
a wide variety of men who suffer from ED, including those with
high blood pressure," said Dr. Parker.
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In the journal-published study, the efficacy
of Viagra was assessed in 3,414 men, of whom 1,218 were taking
antihypertensive medication. In ten double-blind
placebo-controlled studies, participants received Viagra or
placebo (sugar pill) over periods of six weeks to six months.
Significant improvements in erectile
function demonstrated by
Viagra-treated men were
comparable in patients taking high blood pressure medication and
those not taking hypertensive medication. For men taking Viagra
and high blood pressure medication and those not taking
hypertensive medication, Viagra enabled both groups to have
significantly enhanced erections minimal or any side effects.
"The recent study demonstrates that men
with high blood pressure can enjoy the benefits of
Viagra,
even if they are on antihypertensive medicines," concluded Dr.
Parker.
Viagra is a prescription medication
available only from doctors and should always be used in
accordance with its approved labeling. In clinical trials, there
was no difference in the rate of serious cardiovascular events
between patients treated with Viagra or placebo (sugar pill).
While it is well tolerated and effective when used as
prescribed, Viagra should not be taken by patients who use
nitrates.
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Erectile Dysfunction Patients Remain
Satisfied With Viagra After Five Years, New Study Shows
PR Newswire
September, 2008
Long-term Use Od Viagra Analysis
Demonstrates Consistency With Safety Experience in Clinical
Trials
An overwhelming majority of patients
(greater than 95% taking Pfizer Viagra said they remained
satisfied with the
impotence medication after two
years, according to data presented here today at the annual
meeting of the European Urological Association.
In a five-year study involving 4010
patients, participants were asked every three months whether
they were satisfied with the effect Viagra had on their
erections. After five years of treatment, 95 percent of patients
taking Viagra reported they remained very happy with Viagra's
continued ability to enhance their erections.
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The average age of the men
who participated in the study was 55, and each had suffered from
ED for an average of 6.5 years. Further, 16 percent of patients
in the study also suffered from hypertension, 8 percent suffered
from depression, 5 percent were diagnosed with ischemic heart
disease and 4 percent had diabetes.
Separately, data from the longest-term
safety analysis of Viagra showed that Viagra remained a safe and
well-tolerated treatment option for men with
impotence. The incidence of all
myocardial infarctions -- or heart attacks -- was tracked in
more than 6,500 patients who participated in 43
placebo-controlled clinical trials. The incidence of myocardial
infarction was O.84 per 100 patient years for men receiving
Viagra and 1.05 per 100 patient years among those receiving
placebo (sugar pill). There is no statistically significant
difference between these figures.
Impotence is a serious medical condition
that affects an estimated 30 million European men and their
partners.
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the Viagra information topics
Using Viagra
Family Physician
September, 2008
What is Viagra?
Viagra is the brand name for sildenafil.
It's a medicine that helps men with
impotence have sex again. Viagra
has been shown to significantly enhance a man's erections.
Viagra remains the most popular erection enhancement drugs, more
Viagra is sold than all the other erections enhancement drugs
combined.
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What is impotence?
Impotence is the inability of the penis to
become rigid, or to stay rigid long enough to complete the sex
act.
How should I take Viagra?
Take one tablet one hour before you plan to
have sex. Don't take more than one tablet in 24 hours. Viagra
comes in tablets of 25 mg, 50 mg and 100 mg. The standard dose
of Viagra is 50 mg
Even if you take Viagra, you still need
physical and mental stimulation and desire to have an erection.
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of the Viagra information topics
Viagra Tale: How One Man Sought an Impotence
Cure - and Found One.
News & World Report
October, 2008
How one man sought an impotence cure--and
found one
This is a report from Viagra's front lines.
It is from a married man in his early 50s--a friend of this
writer who has tried out Pfizer's new impotence drug. Call him
X; he does not want his name used. And call him grateful; Viagra
worked for him. Is it a wonder drug? The 75,000 prescriptions
written for Viagra in the first two weeks after Viagra came to
market that many hope it could be--and the potential
market numbers as many as 30 million European men, a significant
share in their 40s or even younger.
Mechanically, an erection must accomplish
two goals. Blood must flow vigorously into three parts of the
penis stuffed with erectile tissue that absorbs the blood like a
sponge. And the muscles in the penis and the valves in the veins
leading away must keep the blood from leaking out. When a
patient complains about impotence, a physician first looks for a
history of diabetes or cardiovascular problems, because the
circulation disorders that often accompany these conditions can
interfere with an erection.
Candor difficulties. X, who has been married
about 30 years, began experiencing erectile dysfunction--now the
preferred medical term for impotence--about four years ago. He
could achieve an erection but could sustain it less and less
often. Seeking medical advice didn't help. During a physical
exam, the internist posed his usual inquiry about personal
problems. "I said something like, 'Well, I've been having some
sexual difficulties,' " says X. "He looked at me and made a
note but didn't ask anything else, and I just dropped it. I got
the impression that he really didn't want to discuss it, and I
was self-conscious enough as it was. "This conversation echoed
an assertion by the National Institutes of Health, in a 1992
report on impotence, that "embarrassment of patients and the
reluctance of both patients and health care providers to discuss
sexual matters candidly contribute to under diagnosis."
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The physician and patient had similar non
conversations over the next couple of years. Meanwhile, X's
ability to perform slipped from occasional to rare and, then,
inexorably, never. X's relationship with his wife slowly
chilled. "I felt as if we were work colleagues," says X. "We'd
go places, we'd get done what we had to do around the house, but
there was this huge, dark subject we wouldn't discuss."
Last February, X mustered the nerve to push
his doctor. That won a referral to a urologist. Once the
specialist learned of X's history of heart disease, he didn't
bother with a physical examination. Nor did he think X needed
specialized tests. "I am 99 percent certain that you've got a
circulation problem," he informed X.
The doctor said X could try mechanical
contrivances like a vacuum cuff or pump. Or he could have
bendable rods surgically implanted. Or, using a small, fine
needle, he could inject alprostadil, a drug that mimics a
natural substance produced during sexual arousal, into the
penis, to encourage blood flow. X did not care for any of these
options.
Priapism warnings. His reaction was slightly
less negative to the urologist's final proposal: a tiny
alprostadil suppository placed about an inch into the opening of
the penis with the aid of a special insertion device. Made by
Vivus and called the MUSE system, it produces an erection 20 to
30 percent of the time, and X thought it seemed somewhat less
onerous than the other methods.
Yet many men who try MUSE abandon it because
of insertion discomfort; nearly one third did so in one large
study. The urologist also warned of a small but real danger of
priapism--a painful, ongoing erection that threatens permanent
damage and must be treated at an emergency room. Too, the timing
discourages spontaneity. The drug works five to 10 minutes after
it is administered, during which time sitting, standing, or
walking around is recommended to stimulate blood flow. And
languid dallying is out; the effect wears off after 30 to 60
minutes.
"There's a pill coming out in six months,
Octoberbe less," the urologist told X. "Take the MUSE brochure.
Look it over. See what you think. Octoberbe the thing to do is
to wait for the pill. It's called Viagra."
The $209 visit did warm up the atmosphere at
home. Armed with the MUSE brochure, X was inspired to reveal to
his wife that he had been seeking help. "She was touched," he
says. "She thought I had stopped caring at all." While put off
by the fussy MUSE procedure, she was willing to go along. But X
was due for a follow-up talk with his internist. The couple put
off the MUSE decision until then.
The internist, his interest now piqued,
disagreed with the urologist. X's circulation was fine, he said.
As X lay on the examining table, the internist pressed X's
fingers to the femoral arteries in his groin. "A strong pulse,
right?" The blood vessels to the penis branch off the femoral
arteries, and good femoral circulation argues against poor blood
flow to the penis.
The internist ordered up a testosterone blood test, and the
results made him smile with satisfaction; the number was
extremely low. A depressed level of the male sex hormone, pumped
out by the testes under the control of the pituitary gland in
the brain, does not automatically produce erectile
dysfunction--men with low testosterone can have normal sexual
function--but it might explain X's problem.
X met with an endocrinologist in early
September, and left, for the first time, with hope. The hormone
specialist took a detailed history, including a list of all of
the medications X was taking. He examined X thoroughly,
including a rectal check of the prostate gland. He was
nonjudgmental, empathetic, and eager to answer X's questions.
Moreover, he was flexible. X's testosterone,
he said, could be boosted either by injecting the hormone once
every week or two or with a testosterone skin patch. But the
shots would require frequent visits, or X or his wife would have
to learn to give them.
X was aware that Viagra had come on the
market . Would it make sense to try the new drug before turning
to supplementary testosterone? Sure, replied the
endocrinologist, writing a prescription for 10 pills and asking
X to report back. The most excruciating moment of his four-year
ordeal, says X, was when he approached the pharmacy counter to
pick up his prescription. The clerks at the pharmacy have a
habit of repeating the name of the medication aloud to prevent
mistakes. This time it didn't happen. X was grateful.
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The night X and his wife put Viagra to
the test taught them that the drug is not an aphrodisiac. It
aids an erection but does not cause one. As is true in the
absence of Viagra, stress or nerves play havoc with sexual
response, the couple found. A more relaxed attitude allowed
Viagra to do its work. The phone call to the endocrinologist
would be effusive.
How does Viagra work?
It enhances the effect of nitric oxide. This
chemical is released into the penis during sexual arousal and
relaxes the organ's smooth muscle tissue so that blood flows in,
producing an erection.
Will Viagra help me?
The success rate is about 95 percent.
Problem candidates usually have conditions like poorly managed
diabetes, blocked arteries, or long-standing high blood
pressure.
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How quickly does Viagra take effect?
It can take as long as an hour, but some men
see results in 20 minutes. Most doctors start their patients on
50 milligrams of Viagra but October later alter the dose up to
100 milligrams or down to 25 milligrams. It October take four or
five experiences using Viagra before you learn the dosage and
timing that are best.
How long does the effect last?
Four to six hours, or until orgasm.
How often can I take it?
The approved dosage is no more than one pill
a day. "I know some of my patients, couples who are high-powered
Washington types, who when they finally get away for a weekend
together and want to have some fun are probably going to take
one in the morning and one at night. That most likely will not
cause a problem," says a Washington urologist. It might increase
the possibility of side effects, which occur in up to 10 percent
of men.
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Viagra Wins Medical Innovation
Award
PR Newswire
November, 2000
Viagra , developed and marketed by Pfizer, for the treatment of
male erectile dysfunction (ED), was named last night as joint
winner of the Prix Galien 2000 medical award for scientific
excellence and innovation. The award was presented in London by
Professor Sir Michael Rawlins, Chair of the National Institute
For Clinical Excellence.
Dr Donna McVey, Medical Director for
Pfizer Limited said: ``Viagra has revolutionized the treatment
of erectile dysfunction and brought the subject into the open,
making it easier for patients to seek help. As the first
licensed oral treatment for ED, Viagra has increased
understanding amongst doctors as well as the public that ED has
a significant health impact both for the sufferer and for the
partner. It is very often associated with chronic underlying
illnesses, such as cardiovascular disease, diabetes and
depression. Erection problems affect an estimated 10 per cent of
the male population - that's over 2 million men in the UK. In
many cases, the couple finds it difficult to discuss sexual
problems and many men report that their erection problems
contributed to the break up of their relationship.''
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Presenting the award, Professor Rawlins
said: ``This drug has become a household name. The fact that it
has launched a thousand jokes should not distract us from its
significant benefits; quite apart from being an effective
treatment, it has brought men's health in general, and impotence
in particular, out of the closet. It is innovative, well
tolerated, and provides treatment where existing therapies have
been shown to be suboptimal.''
Prior to the availability of
Viagra,
erectile dysfunction was treated mainly by hospital doctors
because of the invasive nature of treatments available at that
time, such as injections, and the limited experience of GPs in
this area of medicine. The introduction of Viagra and better
training for healthcare professionals during the past two years
means that GPs are now more confident and able to treat ED.
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``We are delighted that this award
recognizes Pfizer's pioneering discovery of the role of PDE5
inhibitors in the treatment of ED,'' commented Dr Gill Samuels,
Senior Director of Science Policy and Scientific Affairs at
Pfizer in Sandwich. ``The research program that produced Viagra
dates back to 1985,'' continued Dr Samuels, ``and is a
remarkable story of innovation, teamwork and commitment. Each
compound that reaches the market represents an investment of
approximately 300 million in research and development, and takes
between ten and fifteen years from the start of a project to
regulatory approval for use. In addition, in the case of Viagra
very few people outside the company even thought it possible to
develop an oral treatment for ED.''
The Prix Galien was launched in France in
1970 by the French pharmacist Roland Mehl. The aim of the award
was, and remains, to promote and encourage research into
therapies which will make a lasting contribution to patient
care. The Prix Galien is recognized within the pharmaceutical
industry as the gold standard award for Innovation in the
development of new medicines.
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of the Viagra information topics
New Study of Viagra in General
Medical Practice Confirms Safety Profile Established by Clinical
Trials.
PR Newswire
October, 2008
Pfizer Inc said today results from the first
stage of a large-scale, post-marketing study of Viagra in
men with erectile dysfunction (ED) confirm the safety profile
established by the extensive clinical trials program.
The independently-conducted observational
study of 5,391 men in the UK found no evidence of increased risk
of heart attack or death from ischemic heart disease associated
with the use of
Viagra. The data were
comparable to UK national health data of the general population
of men of the same age. Men in the study had been prescribed
Viagra in the general practice setting and had been taking the
medicine for an average of five months. Among physicians who
provided an opinion on effectiveness, Viagra was reported to be
effective in 95 percent of patients. The study did not identify
any safety issues.
"With availability of Viagra now having
passed the two-year mark, this study provides important
confirmation that Viagra has an excellent safety profile and is
well tolerated in the wide variety of men who suffer from ED,"
said Joe Feczko, M.D., Senior Vice President for Medical and
Regulatory Operations for the Pfizer Pharmaceuticals Group
(PPG).
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Among the men taking Viagra in the study,
the combined incidence of fatal and non-fatal heart attacks was
7.2 per 1000 person-years and incidence of mortality due to
ischemic heart disease was 3.2 per 1000 person-years. The mean
age of men in the study was 57 years (range 18-89); sixty four
percent of men studied were between the ages of 50 and 69. The
study found that when compared to UK national health data, the
incidence of these findings were similar to that occurring in
the general population of men of the same age. In addition,
the study also found there were no cases of heart attack, stroke
or death reported during the first year after treatment was
prescribed.
"Our interim results are reassuring and did
not produce any surprises," said Saad Shakir, FACP, FFPM, MRCGP,
Director of the Drug Safety Research Unit (DSRU) at Southampton
University, UK, who recently presented the interim results of
the study at the annual meeting of the European Society of
Pharmacovigilance, in Verona, Italy.
Pfizer said that these findings are
consistent with data used to support the approval of Viagra
worldwide. The database of clinical trials currently includes 36
double-blind placebo-controlled trials, including 4,500 men
taking Viagra and over 3,000 men taking placebo. These trials
involved men of different ages, backgrounds and health status,
including men with pre-existing cardiovascular disease.
Discovered and developed by Pfizer,
Viagra
is the breakthrough treatment for erectile dysfunction that was
approved by the U.S. Food and Drug Administration in March 1998
and by the European Commission in Octoberember 1998. The
medicine has since been approved by regulatory authorities in
over 100 countries around the world. Viagra is among the most
widely prescribed medications, with over 25 million
prescriptions written for over 10 million men. More than 300
million tablets have been dispensed worldwide.
The DSRU is an independent organization that
conducts safety studies (called prescription event monitoring
studies) on many new drugs when they first become available by
prescription in the United Kingdom. The DRSU receives charitable
funds from many pharmaceutical companies including Pfizer to
fund its independent research efforts.
Fortunately, secondary to the advent of the internet you can
communicate openly to a physician online. This allows you to
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the Viagra information topics
A MAN AGAIN ': Experts Praise a Pill that
Treats Impotence (the use of the Viagra, an impotence drug)
Maclean's
September, 2008
In December, 1994, Lorne had just turned 40
and life was good. Married, he had two young children, a house
near London and a job he enjoyed. Then disaster struck: as he
changed a tire on his car beside a roadway, another automobile
hit him. Though Lorne can walk and is about to go back to work,
the accident damaged spinal nerves and left him with enduring
problems, including numbness in some parts of his body and
distressing limits on his sex life due to difficulties having
and maintaining erections. "It was depressing," he recalls,
"when my wife was in the mood for sex and I just wasn't
interested." Doctors suggested remedies involving pumps and
injections, but Lorne was not interested in them. Then, he
had the opportunity to take part in clinical trials for a new
drug called Viagra that is designed to deal with problems like
his. In December, 1996, Lorne began popping a sky-blue tablet
whenever sex was in the offing. Once again, his life was
transformed. "Sex is as good as it used to be-Octoberbe even a
little better," he says. "This medication is just fantastic."
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Thousands of European men appear to agree.
Since Viagra was approved for sale in the Europe, demand has
soared to the point that physicians are scribbling an estimated
40,000 prescriptions a day. Manufactured by New York City-based
Pfizer Inc., Viagra-which has yet to be cleared for general use
in Canada-can apparently restore virility in about 80 per cent
of men who have problems, with only minor side-effects including
headaches and indigestion. "This isn't just another drug, it's
the drug-the magic bullet we've been waiting for," says Dr.
Sidney Radomski, a urologist at The Toronto Hospital, one of 27
Canadian centres that took part in the clinical testing of
Viagra. "It's going to revolutionize the treatment of impotence.
"
Pfizer developed Viagra after researchers
testing a drug for angina found that it triggered erections in
men. Now, it seems destined to largely replace existing
treatments which-though effective-cause many men to recoil in
horror. The most popular method requires a man who expects to
have sex to use a needle to inject an erection-causing drug into
the side of his penis. Another involves using a vacuum pump to
draw blood into the penis to create an erection, then placing
rubber bands around the base of the organ to keep it erect. "It
was such a performance," says one middle-aged Viagra user, who
lives near Washington. Those methods, he adds, "undermined
erotic moments by taking the spontaneity out of sex."
Unlike older treatments, which can leave
men with erections that last for hours if sex does not occur,
Viagra only becomes effective when a man is sexually aroused.
The drug works by blocking the operation of an enzyme that
normally breaks down a chemical-cyclic GMP-that plays a key role
in maintaining erections. Even though Viagra-assisted erections
subside after intercourse, some men report that the drug can
remain effective for up to 24 hours. "It means that when they
have a sexual thought during the day, they feel a physical
response," says Dr. Rosemary Basson, a sexual medicine
specialist at The Vancouver Hospital, who has prescribed the
drug to 20 men as part of a long-term study. "That says, OK,
you're a man again. It's tremendously important to them."
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At the same time, European doctors say
some men who do not have potency problems are using the drug to
enhance their sexual performance. Dr. Arthur Barnett, a
urologist, expects men will experiment with the
Viagra
"to see if it will give them super erections or an increased
number of erections over a limited period."
Buy Viagra, erection enhancement medication, securely online
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