Viagra
Information and News Articles
(latest information on Viagra)
The following represent a comprehensive list of Viagra articles
that address the use of
Viagra for the treatment of male impotence:
Viagra,
Rationed
British Medical Journal
May, 2008
Viagra
is Licensed in Europe but Rationed in Britain
British Medical Journal
May, 2008
UK
Issues Guidance On Prescribing Viagra.
British Medical Journal
May, 2008
Study
Shows Viagra Safe for Men with Hypertension
Worldwide Biotech
May, 2008
Erectile
Dysfunction Patients Remain Satisfied With Viagra After Two Years,
New Study Shows
PR Newswire
April, 2008
Using
Viagra
Family Physician
April, 2008
Viagra
Tale: How One Man Sought an Impotence Cure - and Found One
News & World Report
May, 2008
New
Study of Viagra in General Medical Practice Confirms Safety Profile
Established by Clinical Trials.
PR Newswire
May, 2008
A
MAN AGAIN ': Experts Praise a Pill that Treats Impotence (the
use of the Viagra, an impotence drug)
Maclean's
April, 2008
Viagra, Rationed
British Medical Journal
May, 2008
Frank Dobson's announcement on prescribing
Viagra was denounced by the BMA as "cruel
and unethical." But doctors found few allies in the press.
As Jennifer Trueland wrote in the Scotsman, the Viagra
debate "shows that the NHS has finite resources and that
it cannot meet every demand" The Evening Standard, however,
was first into the fray : "Doctors do not run
the National Health Service: taxpayers do. But try telling that
to the British Medical Association. It was in the interests of
the taxpayers, and of common sense, that the Health Secretary,
Frank Dobson, announced his new, binding guidelines.... The BMA
needs to be slapped down hard on this."
The Independent argued that "rationing by queueing" was
as old as the NHS, and that, while the 1990s was "the Happy
Decade" (thank you Prozac and Viagra), it would "also
be remembered as the decade in which the rationing of healthcare
started in Britain." The BMA, it claimed, was more concerned
about doctors' priorities than those of the NHS--"as selfish
and irresponsible a vested interest as the worst of the flying
pickets in the 1970s." Doctors had become rebels, and their
leaders rabble rousing trade unionists: "For the BMA to instruct
its members to defy the Government by prescribing as much Viagra
as they think is justified by `clinical need' until the guidelines
take effect is the kind of gesture politics which got Arthur Scargill
where he is today."
" Dobson's
choice" as the media dubbed it, centered around the health
minister's belief that impotence isn't life threatening and doesn't
cause physical pain. "We have to find a sensible balance
between treating men with a distressing condition and protecting
the resources of the NHS to deal with other conditions, for example,"
chose Mr Dobson, "cancer, heart disease, and mental health
problems." Apparently not the mental anguish of impotent
men, though.
General practitioner
David Devlin told the Daily Telegraph: "I think
this is quite unfair. I have more than 100 patients on Viagra
and all are suffering from impotence caused by psychological or
physical disorders. A lot of people consider
Viagra users to be
promiscuous men. This is not true."
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Andrew Marr
of the Observer offered an explanation: "We
had reason to think that his [Dobson's] contribution to the drugs
debate would be to manufacture the filthiest Viagra joke on the
planet. Instead he has changed the National Health Service forever.
This is about values: and unlike his jokes, Dobson's are decent
to the core. A nation which spends taxpayers' money on better
erections, while leaving old ladies to soil themselves and starve
in under-staffed wards, is sick indeed." Marr is convinced
that Dobson's choice is the "clearest act of national drugs
rationing yet." Who could disagree?
Mr Dobson
was firm, doctors were defiant, and Pfizer--manufacturer of Viagra--was
furious but exploring "all its options." For three days
the controversy raged: "Impotence is not a joke, say doctors", while "Impotence is not really
such a serious problem, claims Dobson" (Express 22 January).
The Express applauded as "Dobson strikes right balance on
Viagra" but added a new twist: "And today
The Express reveals that because the drug is registered in Britain,
this country's exchequer makes money from every pill sold across
the world--in theory, more than enough to offset the costs of
prescribing Viagra."
Confused?
The Sun seemed to be as well. The "Sun Man's Sex File"
confessed: "Dear Mr Dobson, I am a Sun journalist and I am
on Viagra--when I can afford it" (22 January). not
doing the trick then? "How dare you suddenly change the rules
of the NHS now, after I have spent the better part of my working
life paying into it? Viagra has been a Godsend." Another
Sun journalist, Richard Littlejohn, was unhappy that the NHS should
"legalise and supply Viagra." Instead,
he offered his own rationing test: "If you're strong enough
to get the cap off the bottle, you can buy it yourself."
Inevitably,
the prime minister made one of his regular forays into the tabloid
press. "We have to be hard on Viagra," he exclusively
told the Mirror. "I personally believe that
the public understands very well that there are certain severe
medical conditions in relation to impotence that should be treated
on the NHS." Do they? "You have got to make a choice
as to priorities."
Rationing
is the word the government dare not mention--prioritization is
more acceptable in "Third Way" terminology--but everyone
else is dispensing it freely. The first rationing skirmishes have
been won in the press by the government, with doctors portrayed
as power crazed idealists rather than patients' advocates. Rationing
is now dearly with us, though the method of making it work remains
elusive. Where will the National Institute of Clinical Excellence
fit in? How might doctors' and patients' views be better considered?
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the Viagra information topics
Viagra is Licensed
in Europe but Rationed in Britain.
British Medical Journal
May, 2008
Admitting
that the decision was primarily because of cost, the health secretary,
Frank Dobson, said: "Media coverage of this drug to date
has created expectations that could prove a serious drain on the
funds of the NHS. If this were to happen, other patients could
be denied the treatment they need. I cannot allow this to happen.
"
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He added:
"The potential availability of Viagra raises issues about
the priority which should be given to the treatment of impotence
on the NHS." He told Channel 4 News that he expected eventual
"limited availability" of Viagral.
Stephen Thornton,
chief executive of the NHS Confederation, praised the government
for realizing that availability of
Viagra on the NHS "would
have led to huge financial problems and organizational chaos for
the health service." He also said that Mr Dobson was right
to "issue guidance to clinicians and health service managers
about how the drug should be rationed."
The Department
of Health has advised health authorities "not to support
the provision of Viagra at NHS expense to patients requiring
treatment for
impotence, other than in exceptional
circumstances which they should require be cleared in advance
for them." It is not yet clear what these exceptional circumstances
would be. However, it was also emphasized that "ministers
have not made any decisions relating to the nature and extent
of any future availability of this drug as part of NHS services."
The NHS spends
about 12m [pounds sterling] annually on impotence treatments,
but with the introduction of oral treatment, demand is expected
to be much higher than at present. The BMA has calculated that
the annual drug bill for
Viagra would exceed 1bn [pounds sterling]
($1.6bn) a year, if all of the men who might benefit were prescribed
the drug. Pfizer insists that the cost of treatment is closer
to 50m [pounds sterling] after five years.
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Roger Kirby,
a consultant urologist at St George's Hospital in London and honorary
secretary of the British Association of Urological Surgeons, was
surprised that a "breakthrough" treatment was rationed,
while the NHS continued to prescribe for constipation and warts.
He has privately prescribed Viagra for nearly 200 patients
and found it "safe and effective." To avoid massive waiting lists,
GPs, if properly educated, should be able to prescribe Viagra for patients with a genuine clinical need, he said.
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the Viagra information topics
UK
Issues Guidance On Prescribing Viagra.
British Medical Journal
May, 2008
The UK government
last week issued draft guidance to doctors on when they could
prescribe Viagra to patients on the NHS.
Doctors' representatives immediately rejected the government's
proposals as "cruel and unethical."
Frank Dobson,
secretary of state for health, said that GPs could prescribe Viagra
and other drug treatments for impotence only to patients who have
undergone prostatectomy or radical pelvic surgery, or have a spinal
cord injury, diabetes, multiple sclerosis, or single gene neurological
disease.
The minister
says that NHS treatment may also be available "in a hospital
setting subject to specialist assessment in those exceptional
circumstances where impotence is causing severe distress."
Doctors will be advised to restrict their prescribing of treatment
for impotence to one treatment a week. Patients not suffering
from one of the named conditions would be able to get a private
prescription. The pills cost about 8 [pounds sterling] each.
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Mr Dobson
pointed out that if Viagra were freely available the cost of treating
impotence could increase 10-fold or more. He said that he wanted
to keep spending to its current level--estimated to be between
10m [pounds sterling] and 12m [pounds sterling] a year. Mr Dobson said, "We have to find a sensible balance between
treating men with a distressing condition and protecting the resources
of the NHS to deal with other patients-for example, with cancer,
heart disease, and mental health problems."
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It concluded
that there was no medical reason why the drug should not be available
on the NHS, nor why it should not be prescribed by GPs with referral
to hospital specialists where appropriate. It also suggested that
ministers should consider the priority given to all the methods
of managing
impotence in the NHS relative to treatments
for other conditions, but that any decision should take into account
equity of access as well as availability of resources.
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The BMA's
General Practitioners Committee took great exception to the proposals
at its meeting last week. It saw them as unworkable and said they
made a cruel and unethical distinction between acceptable and
unacceptable forms of impotence. The committee believes that it
is wrong to distinguish between patients according to the cause
of their
impotence.
Members criticised
the minister's statement that "impotence is in itself neither
life threatening, nor does it cause physical pain." The chairman
of the BMA council, Dr Ian Bogle, said that if those were the
criteria for treatment "they exclude most of my life's work."
Many patients would have to be referred to hospital when they
could be treated by their GPs and this would increase consultants'
workload.
Pfizer, which
makes Viagra, has accused the government of breaching one of the
NHS's principles, that medical treatment should be available to
patients on the basis of clinical need. The company says that
the conditions specified by Mr Dobson represent about 85% of
those who could benefit clinically from Viagra and that the
minister has discriminated against patients with heart and
psychological problems.
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the Viagra information topics
Study
Shows Viagra Safe for Men with Hypertension
Worldwide Biotech
April, 2008
An important study recently published in the
European Journal of Hypertension shows that Viagra, the breakthrough oral
treatment for
erectile dysfunction (ED), has comparable efficacy
for ED for men taking antihypertensive (high blood pressure) medications
concurrent with Viagra, as for men treated with Viagra alone.
As the largest analysis of clinical trial data to date, the study
assessed the efficacy and safety of Viagra in men with ED who
were already taking one or more antihypertensive medications.
Erectile dysfunction
-- the inability to achieve or maintain an erection sufficient
for satisfactory sexual activity -- is a common problem in men
with high blood pressure. In fact, some studies report that one-in-five
men with high blood pressure suffer from ED. According to the
published study results, taking one or more antihypertensive medications
(diuretics, beta blockers, alpha blockers, ACE inhibitors or calcium
channel blockers) had no effect on the effectiveness or side effect
profile of Viagra.
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"Along
with the effect of hypertension itself, some of the medicines
used to treat high blood pressure are felt to have a negative
impact on erectile function," said Dr. John Parker, Cardiologist,
Mount Sinai Hospital and University Health Network Hospitals. "The results of this study of hypertensive
men confirm that Viagra is safe and effective in a wide variety
of men who suffer from ED, including those with high blood pressure,"
said Dr. Parker.
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In the journal-published
study, the efficacy of Viagra was assessed in 3,414 men, of whom
1,218 were taking antihypertensive medication. In ten double-blind
placebo-controlled studies, participants received Viagra or placebo
(sugar pill) over periods of six weeks to six months.
Significant
improvements in erectile function demonstrated by
Viagra-treated
men were comparable in patients taking high blood pressure medication
and those not taking hypertensive medication. For men taking
Viagra
and high blood pressure medication and those not taking
hypertensive medication, Viagra enabled both groups to have
significantly enhanced erections minimal or any side effects.
"The
recent study demonstrates that men with high blood pressure can
enjoy the benefits of
Viagra, even if they are on antihypertensive
medicines," concluded Dr. Parker.
Viagra is
a prescription medication available only from doctors and should
always be used in accordance with its approved labeling. In clinical
trials, there was no difference in the rate of serious cardiovascular
events between patients treated with Viagra or placebo (sugar
pill). While it is well tolerated and effective when used as
prescribed, Viagra should not be taken by patients who use
nitrates.
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Erectile Dysfunction
Patients Remain Satisfied With Viagra After Five Years, New Study
Shows
PR Newswire
April, 2008
Long-term
Use Od Viagra Analysis Demonstrates Consistency With Safety Experience in Clinical
Trials
An overwhelming majority of patients
(greater than 95% taking
Pfizer Viagra said they
remained satisfied with the
impotence medication after
two years, according to data presented here today at the annual
meeting of the European Urological Association.
In a five-year
study involving 4010 patients, participants were asked every three
months whether they were satisfied with the effect Viagra had
on their erections. After five years of treatment, 95 percent of
patients taking Viagra reported they remained very happy with
Viagra's continued ability to enhance their erections.
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The average
age of the men who participated in the study was 55, and each
had suffered from ED for an average of 6.5 years. Further, 16
percent of patients in the study also suffered from hypertension,
8 percent suffered from depression, 5 percent were diagnosed with
ischemic heart disease and 4 percent had diabetes.
Separately,
data from the longest-term safety analysis of Viagra showed that
Viagra remained a safe and well-tolerated treatment option for
men with
impotence. The incidence of all myocardial infarctions -- or
heart attacks -- was tracked in more than 6,500 patients who participated
in 43 placebo-controlled clinical trials. The incidence
of myocardial infarction was O.84 per 100 patient years for men
receiving Viagra and 1.05 per 100 patient years among those receiving
placebo (sugar pill). There is no statistically significant difference between
these figures.
Impotence is a serious medical condition
that affects an estimated 30 million European men and their
partners.
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Using Viagra
Family Physician
April, 2008
What is Viagra?
Viagra is
the brand name for sildenafil. It's a medicine that helps men
with
impotence have sex again. Viagra has been shown
to significantly enhance a man's erections. Viagra remains the
most popular erection enhancement drugs, more Viagra is sold than
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What is impotence?
Impotence is the inability of the penis to
become rigid, or to stay rigid long enough to complete the sex
act.
How should
I take Viagra?
Take one tablet
one hour before you plan to have sex. Don't take more than one
tablet in 24 hours. Viagra comes in tablets of 25 mg, 50 mg and
100 mg. The standard dose of Viagra is 50 mg
Even if you take Viagra, you still need
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Viagra Tale: How One Man Sought an Impotence
Cure - and Found One.
News & World Report
May, 2008
How one man
sought an impotence cure--and found one
This is a
report from Viagra's front lines. It is from a married man in
his early 50s--a friend of this writer who has tried out Pfizer's
new impotence drug. Call him X; he does not want his name used.
And call him grateful; Viagra worked for him. Is it a wonder drug?
The 75,000 prescriptions written for Viagra in the first two weeks
after Viagra came to market that many hope it
could be--and the potential market numbers as many as 30 million
European men, a significant share in their 40s or even younger.
Mechanically,
an erection must accomplish two goals. Blood must flow vigorously
into three parts of the penis stuffed with erectile tissue that
absorbs the blood like a sponge. And the muscles in the penis
and the valves in the veins leading away must keep the blood from
leaking out. When a patient complains about impotence, a physician
first looks for a history of diabetes or cardiovascular problems,
because the circulation disorders that often accompany these conditions
can interfere with an erection.
Candor difficulties.
X, who has been married about 30 years, began experiencing erectile
dysfunction--now the preferred medical term for impotence--about
four years ago. He could achieve an erection but could sustain
it less and less often. Seeking medical advice didn't help. During
a physical exam, the internist posed his usual inquiry about personal
problems. "I said something like, 'Well, I've been having
some sexual difficulties,' " says X. "He looked at me
and made a note but didn't ask anything else, and I just dropped
it. I got the impression that he really didn't want to discuss
it, and I was self-conscious enough as it was. "This conversation
echoed an assertion by the National Institutes of Health, in a
1992 report on impotence, that "embarrassment of patients
and the reluctance of both patients and health care providers
to discuss sexual matters candidly contribute to under diagnosis."
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The physician
and patient had similar non conversations over the next couple
of years. Meanwhile, X's ability to perform slipped from occasional
to rare and, then, inexorably, never. X's relationship with his
wife slowly chilled. "I felt as if we were work colleagues,"
says X. "We'd go places, we'd get done what we had to do
around the house, but there was this huge, dark subject we wouldn't
discuss."
Last February,
X mustered the nerve to push his doctor. That won a referral to
a urologist. Once the specialist learned of X's history of heart
disease, he didn't bother with a physical examination. Nor did
he think X needed specialized tests. "I am 99 percent certain
that you've got a circulation problem," he informed X.
The doctor
said X could try mechanical contrivances like a vacuum cuff or
pump. Or he could have bendable rods surgically implanted. Or,
using a small, fine needle, he could inject alprostadil, a drug
that mimics a natural substance produced during sexual arousal,
into the penis, to encourage blood flow. X did not care for any
of these options.
Priapism warnings.
His reaction was slightly less negative to the urologist's final
proposal: a tiny alprostadil suppository placed about an inch
into the opening of the penis with the aid of a special insertion
device. Made by Vivus and called the MUSE system, it produces
an erection 20 to 30 percent of the time, and X thought it seemed
somewhat less onerous than the other methods.
Yet many men
who try MUSE abandon it because of insertion discomfort; nearly
one third did so in one large study. The urologist also warned
of a small but real danger of priapism--a painful, ongoing erection
that threatens permanent damage and must be treated at an emergency
room. Too, the timing discourages spontaneity. The drug works
five to 10 minutes after it is administered, during which time
sitting, standing, or walking around is recommended to stimulate
blood flow. And languid dallying is out; the effect wears off
after 30 to 60 minutes.
"There's
a pill coming out in six months, maybe less," the urologist
told X. "Take the MUSE brochure. Look it over. See what you
think. Maybe the thing to do is to wait for the pill. It's called
Viagra."
The $209 visit
did warm up the atmosphere at home. Armed with the MUSE brochure,
X was inspired to reveal to his wife that he had been seeking
help. "She was touched," he says. "She thought
I had stopped caring at all." While put off by the fussy
MUSE procedure, she was willing to go along. But X was due for
a follow-up talk with his internist. The couple put off the MUSE
decision until then.
The internist,
his interest now piqued, disagreed with the urologist. X's circulation
was fine, he said. As X lay on the examining table, the internist
pressed X's fingers to the femoral arteries in his groin. "A
strong pulse, right?" The blood vessels to the penis branch
off the femoral arteries, and good femoral circulation argues
against poor blood flow to the penis.
The internist ordered up a testosterone blood test, and the results
made him smile with satisfaction; the number was extremely low.
A depressed level of the male sex hormone, pumped out by the testes
under the control of the pituitary gland in the brain, does not
automatically produce erectile dysfunction--men with low testosterone
can have normal sexual function--but it might explain X's problem.
X met with
an endocrinologist in early April, and left, for the first time,
with hope. The hormone specialist took a detailed history, including
a list of all of the medications X was taking. He examined X thoroughly,
including a rectal check of the prostate gland. He was nonjudgmental,
empathetic, and eager to answer X's questions.
Moreover,
he was flexible. X's testosterone, he said, could be boosted either
by injecting the hormone once every week or two or with a testosterone
skin patch. But the shots would require frequent visits, or X
or his wife would have to learn to give them.
X was aware
that Viagra had come on the market . Would it make
sense to try the new drug before turning to supplementary testosterone?
Sure, replied the endocrinologist, writing a prescription for
10 pills and asking X to report back. The most excruciating moment
of his four-year ordeal, says X, was when he approached the pharmacy
counter to pick up his prescription. The clerks at the pharmacy
have a habit of repeating the name of the medication aloud to
prevent mistakes. This time it didn't happen. X was grateful.
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The night
X and his wife put Viagra to the test taught them that the drug
is not an aphrodisiac. It aids an erection but does not cause
one. As is true in the absence of Viagra, stress or nerves play
havoc with sexual response, the couple found. A more relaxed attitude
allowed Viagra to do its work. The phone call to the endocrinologist
would be effusive.
How does Viagra
work?
It enhances
the effect of nitric oxide. This chemical is released into the
penis during sexual arousal and relaxes the organ's smooth muscle
tissue so that blood flows in, producing an erection.
Will Viagra
help me?
The success
rate is about 95 percent. Problem candidates usually have conditions
like poorly managed diabetes, blocked arteries, or long-standing
high blood pressure.
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How quickly
does Viagra take effect?
It can take
as long as an hour, but some men see results in 20 minutes. Most
doctors start their patients on 50 milligrams of Viagra but may
later alter the dose up to 100 milligrams or down to 25 milligrams.
It may take four or five experiences using Viagra before you learn
the dosage and timing that are best.
How long does
the effect last?
Four to six
hours, or until orgasm.
How often
can I take it?
The approved
dosage is no more than one pill a day. "I know some of my
patients, couples who are high-powered Washington types, who when
they finally get away for a weekend together and want to have
some fun are probably going to take one in the morning and one
at night. That most likely will not cause a problem," says
a Washington urologist. It might increase the possibility of side
effects, which occur in up to 10 percent of men.
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the Viagra information topics
Viagra Wins
Medical Innovation Award
PR Newswire
Nov 22, 2000
Viagra , developed and marketed by Pfizer, for the treatment
of male erectile dysfunction (ED), was named last night as joint
winner of the Prix Galien 2000 medical award for scientific excellence
and innovation. The award was presented in London by Professor
Sir Michael Rawlins, Chair of the National Institute For Clinical
Excellence.
Dr Donna McVey,
Medical Director for Pfizer Limited said: ``Viagra has
revolutionized
the treatment of erectile dysfunction and brought the subject
into the open, making it easier for patients to seek help. As
the first licensed oral treatment for ED, Viagra has increased
understanding amongst doctors as well as the public that ED has
a significant health impact both for the sufferer and for the
partner. It is very often associated with chronic underlying illnesses,
such as cardiovascular disease, diabetes and depression. Erection
problems affect an estimated 10 per cent of the male population
- that's over 2 million men in the UK. In many cases, the couple
finds it difficult to discuss sexual problems and many men report
that their erection problems contributed to the break up of their
relationship.''
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Presenting
the award, Professor Rawlins said: ``This drug has become a household
name. The fact that it has launched a thousand jokes should not
distract us from its significant benefits; quite apart from being
an effective treatment, it has brought men's health in general,
and impotence in particular, out of the closet. It is innovative,
well tolerated, and provides treatment where existing therapies
have been shown to be suboptimal.''
Prior to the availability of
Viagra,
erectile dysfunction was treated mainly by hospital doctors
because of the invasive nature of treatments available at that
time, such as injections, and the limited experience of GPs in
this area of medicine. The introduction of Viagra and better
training for healthcare professionals during the past two years
means that GPs are now more confident and able to treat ED.
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``We are delighted
that this award recognizes Pfizer's pioneering discovery of the
role of PDE5 inhibitors in the treatment of ED,'' commented Dr
Gill Samuels, Senior Director of Science Policy and Scientific
Affairs at Pfizer in Sandwich. ``The research program that produced
Viagra dates back to 1985,'' continued Dr Samuels, ``and is a
remarkable story of innovation, teamwork and commitment. Each
compound that reaches the market represents an investment of approximately
300 million in research and development, and takes between ten
and fifteen years from the start of a project to regulatory approval
for use. In addition, in the case of Viagra very few people outside
the company even thought it possible to develop an oral treatment
for ED.''
The Prix Galien
was launched in France in 1970 by the French pharmacist Roland
Mehl. The aim of the award was, and remains, to promote and encourage
research into therapies which will make a lasting contribution
to patient care. The Prix Galien is recognized within the pharmaceutical
industry as the gold standard award for Innovation in the development
of new medicines.
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the Viagra information topics
New Study of
Viagra in General Medical Practice Confirms Safety Profile Established
by Clinical Trials.
PR Newswire
May, 2008
Pfizer Inc said today results from the first
stage of a large-scale, post-marketing study of Viagra in men with erectile dysfunction
(ED) confirm the safety profile established by the extensive clinical
trials program.
The independently-conducted
observational study of 5,391 men in the UK found no evidence of
increased risk of heart attack or death from ischemic heart disease
associated with the use of
Viagra. The data were comparable to UK national health data of the general
population of men of the same age. Men in the study had been prescribed
Viagra in the general practice setting and had been taking the
medicine for an average of five months. Among physicians who provided
an opinion on effectiveness, Viagra was reported to be effective
in 95 percent of patients. The study did not identify any safety
issues.
"With
availability of Viagra now having passed the two-year mark, this
study provides important confirmation that Viagra has an excellent
safety profile and is well tolerated in the wide variety of men
who suffer from ED," said Joe Feczko, M.D., Senior Vice President
for Medical and Regulatory Operations for the Pfizer Pharmaceuticals
Group (PPG).
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Among the
men taking Viagra in the study, the combined incidence of fatal
and non-fatal heart attacks was 7.2 per 1000 person-years and
incidence of mortality due to ischemic heart disease was 3.2 per
1000 person-years. The mean age of men in the study was 57 years
(range 18-89); sixty four percent of men studied were between
the ages of 50 and 69. The study found that when compared to UK
national health data, the incidence of these findings were similar
to that occurring in the general population of men of the same
age. In addition, the study also found there were no cases of
heart attack, stroke or death reported during the first year
after treatment was prescribed.
"Our
interim results are reassuring and did not produce any surprises,"
said Saad Shakir, FACP, FFPM, MRCGP, Director of the Drug Safety
Research Unit (DSRU) at Southampton University, UK, who recently
presented the interim results of the study at the annual meeting
of the European Society of Pharmacovigilance, in Verona, Italy.
Pfizer said
that these findings are consistent with data used to support the
approval of Viagra worldwide. The database of clinical trials
currently includes 36 double-blind placebo-controlled trials,
including 4,500 men taking Viagra and over 3,000 men taking placebo.
These trials involved men of different ages, backgrounds and health
status, including men with pre-existing cardiovascular disease.
Discovered
and developed by Pfizer,
Viagra is the breakthrough treatment
for erectile dysfunction that was approved by the U.S. Food and
Drug Administration in March 1998 and by the European Commission
in Mayember 1998. The medicine has since been approved by regulatory
authorities in over 100 countries around the world. Viagra is
among the most widely prescribed medications, with over 25 million
prescriptions written for over 10 million men. More than 300 million
tablets have been dispensed worldwide.
The DSRU is
an independent organization that conducts safety studies (called
prescription event monitoring studies) on many new drugs when
they first become available by prescription in the United Kingdom.
The DRSU receives charitable funds from many pharmaceutical companies
including Pfizer to fund its independent research efforts.
Fortunately, secondary to the advent of the
internet you can communicate openly to a physician online. This
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the Viagra information topics
A MAN AGAIN
': Experts Praise a Pill that Treats Impotence (the use of the
Viagra, an impotence drug)
Maclean's
April, 2008
In December,
1994, Lorne had just turned 40 and life was good. Married, he
had two young children, a house near London and a job he enjoyed.
Then disaster struck: as he changed a tire on his car beside a
roadway, another automobile hit him. Though Lorne can walk and
is about to go back to work, the accident damaged spinal nerves
and left him with enduring problems, including numbness in some
parts of his body and distressing limits on his sex life due to
difficulties having and maintaining erections. "It was depressing,"
he recalls, "when my wife was in the mood for sex and I just
wasn't interested." Doctors suggested remedies involving
pumps and injections, but Lorne was not interested in them. Then,
he had the opportunity to take part in clinical trials for a new
drug called Viagra that is designed to deal with problems like
his. In December, 1996, Lorne began popping a sky-blue tablet
whenever sex was in the offing. Once again, his life was transformed.
"Sex is as good as it used to be-maybe even a little better,"
he says. "This medication is just fantastic."
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Thousands
of European men appear to agree. Since Viagra was approved for
sale in the Europe, demand has soared to
the point that physicians are scribbling an estimated 40,000 prescriptions
a day. Manufactured by New York City-based Pfizer Inc., Viagra-which
has yet to be cleared for general use in Canada-can apparently
restore virility in about 80 per cent of men who have problems,
with only minor side-effects including headaches and indigestion.
"This isn't just another drug, it's the drug-the magic bullet
we've been waiting for," says Dr. Sidney Radomski, a urologist
at The Toronto Hospital, one of 27 Canadian centres that took
part in the clinical testing of Viagra. "It's going to revolutionize
the treatment of impotence. "
Pfizer developed
Viagra after researchers testing a drug for angina found that
it triggered erections in men. Now, it seems destined to largely
replace existing treatments which-though effective-cause many
men to recoil in horror. The most popular method requires a man
who expects to have sex to use a needle to inject an erection-causing
drug into the side of his penis. Another involves using a vacuum
pump to draw blood into the penis to create an erection, then
placing rubber bands around the base of the organ to keep it erect.
"It was such a performance," says one middle-aged Viagra
user, who lives near Washington. Those methods, he adds, "undermined
erotic moments by taking the spontaneity out of sex."
Unlike older
treatments, which can leave men with erections that last for hours
if sex does not occur, Viagra only becomes effective when a man
is sexually aroused. The drug works by blocking the operation
of an enzyme that normally breaks down a chemical-cyclic GMP-that
plays a key role in maintaining erections. Even though Viagra-assisted
erections subside after intercourse, some men report that the
drug can remain effective for up to 24 hours. "It means that
when they have a sexual thought during the day, they feel a physical
response," says Dr. Rosemary Basson, a sexual medicine specialist
at The Vancouver Hospital, who has prescribed the drug to 20 men
as part of a long-term study. "That says, OK, you're a man
again. It's tremendously important to them."
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At the same
time, European doctors say some men who do not have potency problems
are using the drug to enhance their sexual performance. Dr. Arthur
Barnett, a urologist, expects men will experiment with the
Viagra "to see if it will
give them super erections or an increased number of erections
over a limited period."
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the Viagra information topics
